Then, for each subject, we can then calculate the difference in balancing time between the two legs. For example, subjects with h ACL tears may be asked to balance on their leg with the torn ACL and then to balance again on their leg without the torn ACL. However, sometimes the two variables are separated by something other than time. We may be interested in the difference in cholesterol levels between these two time points. For example, in the Dixon and Massey data set we have cholesterol levels in 1952 and cholesterol levels in 1962 for each subject. Often the two variables are separated by time. A paired t-test is used when we are interested in the difference between two variables for the same subject.
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